Rui Liu 0000-0002-5002-7311
Investigation of the role of elongation of very long chain fatty acids protein 4 (Elovl4) in head and neck squamous cell carcinoma (tutor: Gerry Melino)
My research project aims to investigate the critical role of Elovl4 in head and neck squamous cell carcinoma (HNSCC). Owing to the requirement of Elovl4 and its products for the development and functionality of skin, Elovl4-mediated very long chain fatty acids biosynthesis can also participate in the process and biology of HNSCC. In my project, I focus on the relationship between Elovl4-mediated lipid metabolism and mitochondrial homeostasis to understand the metabolic mechanisms by which Elovl4 affects HNSCC.
我的研究课题旨在探究Elovl4 在头颈部鳞状细胞癌 (HNSCC) 中的关键作用。 由于 Elovl4及其产物是皮肤组织发育和功能所必须的，因此Elovl4及其介导的极长链脂肪酸的生物合成也将参与到头颈部鳞状细胞癌的发生发展以及生物学改变。在我的课题中，我聚焦于Elovl4介导的脂质代谢以及线粒体稳态之间的关系，以期阐明Elovl4影响头颈部鳞状细胞癌的代谢机制